Upregulation of centromere protein F is linked to aggressive prostate cancers
نویسندگان
چکیده
منابع مشابه
Deletion at 13q21 is associated with aggressive prostate cancers.
Previous cytogenetic and molecular genetic analyses suggest that the q21 band of chromosome 13 harbors a tumor suppressor gene(s) involved in prostatic carcinogenesis. The precise genetic location, however, has not been defined. In this study, we examined prostate cancer specimens and cell lines/xenograft for genetic deletions at 13q21, using the methods of tissue microdissection and duplex PCR...
متن کاملKEN-dependent degradation of centromere protein F
Introduction Successful completion of chromosome segregation and cytokinesis requires the coordinated activation and inactivation of numerous mitotic regulators. Inactivation is largely brought about by ubiquitindependent proteolysis, with the relevant E3 ubiquitin ligase being the anaphase promoting complex, or cyclosome (APC/C) (Irniger et al., 1995; King et al., 1995; Sudakin et al., 1995). ...
متن کاملCENPF (centromere protein F, 350/400ka (mitosin))
DNA/RNA Description The CENPF gene structure consists of twenty exons, ranging from 92 to 3,404 bp, and nineteen introns, ranging from approximately 1 to approximately 10 kb. Transcription 10,294 bp mRNA; 9630 bp open reading frame. Pseudogene No pseudogene. Protein Description The gene encodes a protein associated with the centromere-kinetochore complex, 3210 amino acids (aa), 367594 Da, conta...
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To cancer protein prostate linked. Prostate cancer afflicts one male in every six, and a significant percentage of men have underlying prostate cancer without. the risks of colorectal, breast, and prostate cancer, medical researchers have found. protein linked to prostate cancer www.bcm.tmc.edu/baylormed September, 2000 Gene Identified .... Find out about the symptoms and treatment options 1-8-...
متن کاملSerum Fucosylated Prostate-specific Antigen (PSA) Improves the Differentiation of Aggressive from Non-aggressive Prostate Cancers
BACKGROUND Clinically, it is still challenging to differentiate aggressive from non-aggressive prostate cancers (Pca) by non-invasive approaches. Our recent studies showed that overexpression of alpha (1-6) fucosyltransferase played an important role in Pca cells. In this study, we have investigated levels of glycoproteins and their fucosylated glycoforms in sera of Pca patients, as well as the...
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ژورنال
عنوان ژورنال: Cancer Management and Research
سال: 2018
ISSN: 1179-1322
DOI: 10.2147/cmar.s165630